![]() To investigate the prevalence of frailty among the three age groups and consider the higher attrition rate in the oldest age group, the KFACS cohort adopted quota sampling stratified by age (70–74, 75–79, and 80–84 years, with a ratio of 6:5:4). 11) The participants were recruited from urban, suburban, and rural communities nationwide. The baseline survey for the cohort study was conducted at 10 centers, with 1,559 participants in 2016 and 1,455 in 2017. The KFACS is a nationwide multicenter longitudinal study with a baseline survey conducted in 20 to identify factors contributing to frailty and aging in community-dwelling individuals aged 70–84 years. Therefore, we investigated the relationship between functional constipation and cognitive decline in community-dwelling older adults using the Korean Frailty and Aging Cohort Study (KFACS) longitudinal database. However, no prospective cohort study has yet explored the predictive effects of functional constipation on cognitive decline. 10) showed that a higher prevalence of constipation is associated with dementia and non-amnestic mild cognitive impairment. In a cross-sectional population-based cohort study, Wang et al. 9) found that constipation predicts cognitive decline in Parkinson disease. 8)Īs an important manifestation of autonomic nerve dysfunction, constipation is well known to be the most common non-motor complication of Parkinson disease. Therefore, identifying the risk factors for cognitive impairment is essential for preventing cognitive disorders and can help promote successful cognitive aging. 7)Ĭognitive impairment is a major personal and public health problem in older adults. Functional constipation has been reported in 30%–40% of older adults worldwide 6) and 19.6% of Korean adults aged 72–86 years. 4) The worldwide prevalence of functional constipation in adults is 10.1%, 5) and the prevalence of functional constipation increases with age. 1 - 3) Functional constipation was defined by the Rome Foundation to help standardize the diagnosis of chronic constipation without physiological abnormalities identified by routine diagnostic examinations, as deemed clinically appropriate. Constipation is an unsatisfactory defecation disorder characterized by infrequent stools, difficult stool passage, or both, and it is one of the most common health problems encountered in older adults.
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